ENZYME SUPPLEMENT

ENZYME SUPPLEMENT

$60.00
$60.00 $79.99
SAVE 24% Sold out

A digestive enzyme blend that breaks down the most common FODMAP triggers.* Enjoy garlic, onion, bread, beans, and dairy without the aftermath.

BUNDLE & SAVE

ENZYME SUPPLEMENT

ENZYME SUPPLEMENT

$60.00
$60.00 $79.99
SAVE 24% Sold out

How to use

Step 1

Allow hot foods to cool slightly before applying (below 140 °F / 60 °C).

Step 2

Mix directly or apply evenly on meals. It’s tasteless.

Step 3

Can’t mix? Sprinkle and chew with first bite.

Step 4

Double dose if extra sensitive or for large meals.

Ingredients

Fructan Hydrolase: One of FODZYME’s core innovations, this enzyme helps break down fructans and inulin found in foods like garlic, onions, and wheat.
Alpha-galactosidase: Targets GOS (galacto-oligosaccharides) present in beans and legumes, aiding digestion.
Lactase: Simplifies the digestion of lactose, commonly found in dairy products.
Dextrin: Sourced from non-GMO maize/corn, used to stabilize the enzymes, ensuring they remain effective throughout digestion.
Contains no GMOs, gluten, milk, egg, casein, soy, or artificial colors or flavors.

Dosage

FODZYME comes in two serving formats with the exact same enzyme blend in each. The Home Kit provides 0.75g per serving, which is our standard serving for meals at home where you typically have more visibility into ingredients. The On-the-Go Kit provides 1g per serving—a larger serving of the same product to help cover the hidden FODMAPs that are more common in restaurant meals. The Anywhere Bundle includes both the Home Kit and the On-the-Go Kit.
Serving size is not based on body weight or age. Instead, it depends on the size of the meal and its FODMAP content. Our servings are designed to work well for most customers and are based on the average amount of FODMAPs in meals and typical tolerance levels.

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How It Works

  • STEP1
    Allow hot foods to cool slightly before applying .

  • STEP 2
    Mix directly or apply evenly on meals. It's tasteless.

  • STEP 3
    Can't mix? Sprinkle and chew with first bite.

  • STEP 4
    Double dose if extra sensitive or for large meals.

    Meals Made Painless

    Evidence & Research

    Of fructan mass degraded within 30 minutes in a peer-reviewed simulated gastrointestinal study (Castro Ochoa et al., Gastro Hep Advances, 2023).1

    Reported improvement in bloating and flatulence from FODMAP ingestion after 4 weeks (Kaye et al., Gastro Hep Advances, 2026; P<.01).2

    Reported improvement in constipation from FODMAP ingestion after 4 weeks (Kaye et al., Gastro Hep Advances, 2026; P<.01).2

    Simulator of the Human Intestinal Microbial Ecosystem (SHIME®)

    FODZYME® is supported by two peer-reviewed publications in Gastro Hep Advances. In a SHIME® study (Castro Ochoa et al., 2023), it degraded 90% of fructans within 30 minutes while preserving short-chain fatty acid (SCFA) and butyrate production — unlike a strict low-FODMAP diet, which depletes SCFAs critical for colonic microbiome health. In an IRB-approved clinical cohort study independently analyzed at SUNY Downstate (Kaye et al., 2026), 78% of participants reported improvement in bloating and flatulence from FODMAP ingestion after 4 weeks, with significant improvements in quality of life and mental well-being (all P<.01).

    1. Castro Ochoa K, Samant S, Liu A, Duysburgh C, Marzorati M, Singh P, Hachuel D, Chey W, Wallach T. In Vitro Efficacy of Targeted FODMAP Enzymatic Digestion in a High-Fidelity Simulated Gastrointestinal Environment. Gastro Hep Advances. 2023;2(3):283-290. doi:10.1016/j.gastha.2022.10.011
    2. Kaye AJ, Meyers SR, Hachuel D, Wells J, Wallach T, Thor S. FODMAP-Targeting Digestive Enzyme Blend for Management of Gastrointestinal Symptoms: A Real-World Pre-Post Intervention Cohort Study. Gastro Hep Advances. 2026;5(4):100898. doi:10.1016/j.gastha.2026.100898

    In Control,Wherever You Are.

    FODZYME® Home Kit

    Your everyday essential. A jar built for the kitchen counter.

    FODZYME® On-The-Go Kit

    Our most powerful dose yet. 33% more enzyme activity - ideal for dining

    Tasteless Formulation

    ACTIVE INGREDIENTS:

    ENZYME BLEND (32MG PER G) 

    Our fructan hydrolase is the first ever enzyme to target fructans like inulin, fructo-oligosaccharides (FOS), and levan.

    Our alpha-galactosidase enzyme can effectively break down the galacto-oligosaccharides (GOS) or galactans (“O” in FODMAPs).

    Our lactase enzyme (also called β-D-galactosidase) can break down lactose (the “D” in FODMAPs).

    FODZYME® is formulated as a tasteless powder to ensure maximum contact between its digestive enzymes and FODMAP-containing foods, allowing for more effective breakdown of FODMAPs during digestion. Unlike capsules, the powder mixes directly with food, optimizing enzyme performance and supporting better digestive relief.Our formulation consists of clinically and scientifically studied microbial enzymes characterized at both academic institutions, and research partners.

    Eating out doesn't have to be scary.

    With FODZYME®, you can be confident that you'll have smoother
    digestion after evry meal!
    With our On-the-Go Kit, you can take FODZYME® with youwherever you need so you don't have to worry about an upsetstomach.
    Dining out or at a friends house doesn't have to cause anxiety.FODZYME® can break down these problem foods before theycause a problem.

    Not a Probiotic. Not a Pill.

      Others
    Engineered specifically to break down FODMAPs
    Powder form for superior efficacy
    Scientifically validated
    Rigorously tested
    Certified low-FODMAP

    Our Scientific Advisory Board Includes Experts In Gastroenterology, Biotechnology, Computational Biology, And Nutrition, Representing World-Class Institutions.

    • William D. Chey, MD

      Advisor, Professor of Gastroenterology at the University of Michigan and Board member at the American College of Gastroenterology (ACG) and Rome Foundation

    • Shalaka Samant, PhD

      Founding Scientist at Kiwi Biosciences, former postdoctoral researcher at the Yale University School of Medicine

    • Thomas Wallach, MD

      Advisor, Assistant Professor at SUNY Downstate Medical Center, Pediatric Gastroenterology

    • Jocelyn Wells, MS, RDN

      A dietitian with a Master's in Clinical Nutrition, Jocelyn leads FODZYME®'s healthcare partnerships. She bridges the latest research in digestive health and nutrition guidelines to help clinicians bring digestive relief to patients navigating IBS and FODMAPs.

      Hi 👋, We’reCo-FoundersAnjie and David!

      Anjie Liu

      Anjie created FODZYME® after battling IBS and thelimitations of a low-FODMAP diet. A Harvard-trainedphysicist and Forbes30 Under 30 honoree,sheleadswithapersonal mission: to help people enjoy food without

      David Hachuel MPH

      David brings deep experience in gut health technology,including founding auggi.ai (acquired by Seed Health). Withdegrees from Harvard, NYU, and Cornell, he drivesFODZYME®'s science, product.

      Q&A

      What exactly is FODZYME®

      Founded by an IBS sufferer, FODZYME® is a tasteless enzyme powder that breaks down FODMAPs — fermentable carbohydrates that trigger bloating, gas, diarrhea, constipation, and abdominal pain. It contains three active enzymes: fructan hydrolase (the first commercially available enzyme targeting fructans in garlic, onion, and wheat), alpha-galactosidase (for GOS in beans and legumes), and lactase (for lactose in dairy). FODZYME® is mixed directly with food before eating, manufactured in the USA, and independently certified low-FODMAP by Monash University.

      What ingredients does FODZYME® contain?

      • Fructan Hydrolase: One of FODZYME’s core innovations, this enzyme helps break down fructans and inulin found in foods like garlic, onions, and wheat.
      • Alpha-galactosidase: Targets GOS (galacto-oligosaccharides) present in beans and legumes, aiding digestion.
      • Lactase: Simplifies the digestion of lactose, commonly found in dairy products.
      • Dextrin: Sourced from non-GMO maize/corn, used to stabilize the enzymes, ensuring they remain effective throughout digestion.

      Is FODZYME® allergen-friendly?

      Yes, FODZYME® is:

      • Certified low FODMAP by Monash University and FODMAP Friendly
      • Vegan-friendly
      • Non-GMO
      • Gluten-free
      • Dairy-free
      • Soy-free
      • Egg-free
      • Casein-free
      • Free from artificial colors and flavors
      • Manufactured in the USA with global ingredients
      • Certified Kosher by Kosher Supervision of America (KSA)

      What foods does FODZYME® help digest?

      FODZYME® targets three primary FODMAP groups—fructans, galacto-oligosaccharides (GOS), and lactose—which are common triggers for digestive discomfort. Its enzyme blend works on foods like garlic, onions, wheat, beans, lentils, dairy products, and certain vegetables, breaking these FODMAPs into easily digestible sugars.

      Key Food Groups Supported and Example Foods:

      • Fructans:Garlic, onions, leeks, wheat, barley, asparagus, artichokes, Brussels sprouts, and cashews.
      • GOS:Chickpeas, lentils, black beans, red kidney beans, soy milk (whole bean), pistachios, and oats.
      • Lactose:Milk, yogurt, ice cream, soft cheeses (ricotta, cottage cheese), and cream.

      How do I take FODZYME®?

      1. Mix Directly:Mix FODZYME® directly or apply evenly on meals. It’s tasteless.
      2. Alternate Method:If you can’t mix, sprinkle FODZYME® and chew with the first bite.
      3. Adjust Dosage:Dosage is personal—double the dose if extra sensitive or for large meals.
      4. Temperature Note:Allow hot foods to cool slightly before applying (below 140 °F / 60 °C). As a rule of thumb, adding FODZYME® is okay if the meal is cool enough that it won’t burn.
      5. Enjoy:Chew well and enjoy your meal!

      How quickly does FODZYME® work? When will I feel something?

      FODZYME® begins breaking down FODMAPs immediately upon contact with food. In a peer-reviewed study (Castro Ochoa et al., Gastro Hep Advances, 2023), it degraded up to 90% of fructans within 30 minutes under simulated gastric conditions. This rapid action breaks down FODMAPs in the stomach and upper small intestine — before they reach the colon where bacterial fermentation causes bloating and gas.

      Most users notice the absence of their usual symptoms 4–8 hours after a FODMAP-rich meal, consistent with normal gastrointestinal transit time. In an IRB-approved clinical study (Kaye et al., Gastro Hep Advances, 2026), 78% of participants reported improvement in bloating and flatulence from FODMAP ingestion after 4 weeks (P<.01).